2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-Y0682R
    Ethylenediaminetetraacetic acid (Standard) 60-00-4
    Ethylenediaminetetraacetic acid (Standard) is the analytical standard of Ethylenediaminetetraacetic acid. This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research[4].
    Ethylenediaminetetraacetic acid (Standard)
  • HY-Y0921R
    (±)-1,2-Propanediol (Standard) 57-55-6
    (±)-1,2-Propanediol (Standard) is the analytical standard of (±)-1,2-Propanediol. This product is intended for research and analytical applications. (±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish.
    (±)-1,2-Propanediol (Standard)
  • HY-Y0921S
    (±)-1,2-Propanediol-d8 80156-55-4 98%
    (±)-1,2-Propanediol-d8 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents.
    (±)-1,2-Propanediol-d8
  • HY-Y1176S
    Isonipecotic acid-d9 1219798-43-2 98%
    Isonipecotic acid-d9 is the deuterium labeled Isonipecotic acid. Isonipecotic acid is a GABAA receptor partial agonist.
    Isonipecotic acid-d9
  • HY-Y1373R
    Cyclohexanecarboxylic acid (Standard) 98-89-5
    Cyclohexanecarboxylic acid (Standard) is the analytical standard of Cyclohexanecarboxylic acid. This product is intended for research and analytical applications. Cyclohexanecarboxylic acid is a Valproate structural analogue with anticonvulsant action.
    Cyclohexanecarboxylic acid (Standard)
  • HY-Y1373S
    Cyclohexanecarboxylic acid-d1 933-37-9 98%
    Cyclohexanecarboxylic acid-d1 is the deuterium labeled Cyclohexanecarboxylic acid. Cyclohexanecarboxylic acid is a Valproate structural analogue with anticonvulsant action.
    Cyclohexanecarboxylic acid-d1
  • HY-100046R
    Nordoxepin hydrochloride (Standard) 2887-91-4
    Nordoxepin (hydrochloride) (Standard) is the analytical standard of Nordoxepin (hydrochloride). This product is intended for research and analytical applications. Nordoxepin hydrochloride is the major metabolite of Doxepin. Doxepin is a tricyclic antidepressant that is widely prescribed for the research of mild depression.
    Nordoxepin hydrochloride (Standard)
  • HY-100119A
    Enecadin hydrochloride 178429-67-9 98%
    Enecadin hydrochloride is a neuroprotective agent extracted from patent US 8623823 B2.
    Enecadin hydrochloride
  • HY-100159A
    Ipenoxazone hydrochloride 118635-68-0 98%
    Ipenoxazone (MLV-6976) hydrochloride is a potent and centrally acting muscle relaxant.
    Ipenoxazone hydrochloride
  • HY-10019S1
    Varenicline-15N,13C,d2 98%
    Varenicline-15N,13C,d2 is 15N and deuterated labeled Varenicline (HY-10019). Varenicline (CP 526555) is an orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC50=250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of α6β2 nAChR and a full agonist of α7β2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation.
    Varenicline-15N,13C,d2
  • HY-100243A
    Norcisapride 83863-69-8 98%
    Norcisapride is a metabolite of cisapride (HY-14149). Norcisapride can be converted into UNK under CYP3A4.
    Norcisapride
  • HY-100426A
    Osemozotan hydrochloride 137275-80-0 98%
    Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder.
    Osemozotan hydrochloride
  • HY-100530A
    Rp-cAMPS 73208-40-9 98%
    Rp-cAMPS, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS is resistant to hydrolysis by phosphodiesterases.
    Rp-cAMPS
  • HY-10053S1
    Maropitant-13C,d3 98%
    Maropitant-13C,d3 is the 13C- and deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting.
    Maropitant-13C,d3
  • HY-100616A
    trans-ACBD 117488-23-0 98%
    trans-ACBD (trans-1-Aminocyclobutane-1,3-dicarboxylic acid) is a very potent and selective NMDA receptor agonist that modulates glutamatergic neurotransmission.
    trans-ACBD
  • HY-100634R
    4-Hydroxypropranolol hydrochloride (Standard) 14133-90-5
    4-Hydroxypropranolol (hydrochloride) (Standard) is the analytical standard of 4-Hydroxypropranolol (hydrochloride). This product is intended for research and analytical applications. 4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol. 4-Hydroxypropranolol hydrochlorid is of comparable potency to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties.
    4-Hydroxypropranolol hydrochloride (Standard)
  • HY-100642S
    3-O-Methyltolcapone-d7 ≥99.0%
    3-O-Methyltolcapone-d7 is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease.
    3-O-Methyltolcapone-d7
  • HY-100651R
    Desmethylnortriptyline (Standard) 4444-42-2
    Desmethylnortriptyline (Standard) is the analytical standard of Desmethylnortriptyline (HY-100651). This product is intended for research and analytical applications. Desmethylnortriptyline is a metabolite of Nortriptyline (HY-118620). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline (HY-B0527) , and is used to relieve the symptoms of depression.
    Desmethylnortriptyline (Standard)
  • HY-100665R
    Dehydroaripiprazole (Standard) 129722-25-4
    Dehydroaripiprazole (Standard) is the analytical standard of Dehydroaripiprazole. This product is intended for research and analytical applications. Dehydroaripiprazole (OPC-14857) is an active metabolite of Aripiprazole (HY-14546) and dopamine D2/D3 receptor partial agonist. Dehydroaripiprazole also has certain affinity for serotonin 5-HT1A, 5-HT2A and 5-HT2B receptors. Dehydroaripiprazole has antipsychotic activity equivalent to Aripiprazole.
    Dehydroaripiprazole (Standard)
  • HY-100703A
    Pipamperone dihydrochloride 2448-68-2 98%
    Pipamperone dihydrochloride (Floropipamide dihydrochloride) is a butyrophenone derivative and high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0). Pipamperone dihydrochloride is also a low-affinity antagonist of D2 receptor (pKi=6.7). Pipamperone dihydrochloride affects neurotransmitter functions and exerts antipsychotic activity. Pipamperone dihydrochloride is used in the research of mental disorders such as autism-related behavioral disorders and Alzheimer's disease.
    Pipamperone dihydrochloride
Cat. No. Product Name / Synonyms Application Reactivity